Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health

Judge for yourself.
如果你没听过这句话,你去年绝对没上过中文网。这句简单的话是留在魔兽BBS上的,不知道什么原因——有说法是有网络公司是幕后推手——这句话吸引了710万人点击,在发布后24小时内产生了30万条评论。
n. 锦标赛,冠军,拥护
16. Zapier
4. 2012年搞笑诺贝尔奖之神经科学奖
smiles and puma snarls
为了让故事更符合现代读者的口味,新作加入了一些“小花样”,包括吸烟会导致癌症的广告词以及一位跟邦德不相上下的女性。
Zhou Qunfei from Lens Technology, the major touchscreen maker, ranks third on the list with a net worth of 45 billion yuan.
Challenger说:“工作总会有的。公司总是在招聘,只是竞争更加残酷了。”
There are, for example, clear differences in the way the products are pitched to investors in the US and Asia. A high proportion — some estimate 90 per cent — of funds in Asia are commission-based. This disadvantages ETFs because they are openly traded on stock exchanges and are not structured to pay commissions to banks, brokerages or financial advisers that might recommend them, unlike the mutual fund industry in the region.
两周后,伯恩海默等几十位著名的早期绘画大师作品交易商出席伦敦的夜间拍卖会。过去,他们通常会在这些拍卖会上购买一些作品,以备在第二年3月的荷兰马斯特里赫特欧洲美术博览会(Maastricht European Fine Art Fair)上展示。但是由于卖家们鼓励苏富比和佳士得报出更高的估价来争夺自己的拍品,所以拍卖行只针对少数富豪进行宣传,现场竞价十分冷清。
I want to be in your arms this New Year.我要在你的怀抱里度过今年的春节。
Tuesday’s event at Apple’s new Cupertino headquarters is expected to reveal its much-anticipated 10th-anniversary iPhone, offering significant upgrades to the smartphone’s display, camera and overall design.
'My first duty, my first responsibility was to be true to the original feel of the book, to be true to Ian Fleming: his creation, his world and his ideas.
['v?:tju:]
available
500富人榜中20%的富豪来自信息技术行业,而资产投资者正逐渐淡出该榜单。
2016年,中国电影票房经历了一次令人震惊的调整,从2015年的48%大幅下降到3.7%。
“他们说:‘我会奇怪她为什么在会议的时候低着头;我好奇她为什么不再兴奋地接过这个案子;我也会想她为什么一周有两天很早地离开,”凯说,“你在他们的脑海里引发了这些问题。”
recept接受+ive表形容词→善于接受的
你是个大忙人,经常会觉得事情多得忙不过来。而Asana是一款基于云计算的项目管理软件,它能够帮你把各项工作统筹起来。(相信我,我试用过所有类似软件。)灵活性是Asana软件架构的一大特点,每个“任务”或“子任务”都可以与一个更大的“项目”和“部门”联系起来。另外,你还可以为自己或你的团队设置周期性任务,从而使你的工作生活更加轻松。因为你不必再去记住所有要做的事,大可放心让Asana安排你的生活。
[iks'tr?v?g?nt]
[si'lebriti]
4. 外包就业服务
在苹果今年6月举行的全球开发者大会(Worldwide Developer Conference)上,库克被应用开发者团团围住,要求与他自拍合影。到了10月的iPad发布会,他甚至自己讲起了笑话。他还是一贯的着装,简单朴实:黑衬衫,牛仔裤,衬衫下摆散着。他说,Apple Watch得到了“深谙时尚与风格——比我还懂的人”的热烈好评,一边说,一边心照不宣地指着轻声发笑的观众。


“写这本书的一大挑战是异性恋男人能改变一个女人的生活并使她死心塌地的看法。”
这位腾讯公司员工说道:“我们希望她的妈妈能出面协助我们一起调查此事。如果用户确实13岁,未经允许花钱,那么我们可以协调退还。”
Its alumni enjoyed by far the greatest financial rewards, with an average salary of $469,000 three years after graduation.


With the increasing proliferation and sophistication of mobile phones, wearable devices such as smart watches, and sensors that can measure and gather a variety of data, public interest is growing in using consumer electronics to take ownership of personal health and wellness. A 2015 survey found that 66% of Americans age 66 and older want to use mobile technologies to improve their health by receiving medication reminders and tracking diet and nutrition, physical activity, and symptoms.[1

恭贺新禧,万事如意。
英国独立党(UKIP)前领袖杰尔.法拉奇(Nigel Farage)略逊一畴,就是因为事实证明攻破英国基于党派的制度比美国总统选举更难。
In P2P lending, borrowers are matched with investors, who are encouraged to put their money into the loans due to higher returns than they could get at state banks.
“The employee said she was going out to buy boots, but was never seen again.”

Health apps and wearables
Health apps and wearables can unobtrusively gauge physiological and emotional states and collect, quantify, and monitor data regarding a user’s day-to-day behaviors. This “quantified self” can increase users’ self-awareness regarding their behavior and encourage positive changes to their overall health and well-being.[2] These commercially available devices also integrate an array of features to provide motivation through reward systems, opportunities for social in-teraction, tools for self-improvement, and prompts. The novelty, affordability, practicality, and ease of use have resulted in increased consumer enthusiasm and the pervasiveness of these devices.[3,4] With this growing interest in personal health, members of the general public are becoming more involved in monitoring and improving their own health habits.[5-10

Undoubtedly, merely tracking data through a device is not enough to maintain good health-related behaviors long-term, and the software must also incorporate motivational constructs important for the adoption and habituation of behaviors. For instance, a systematic review of studies that considered the use of electronic activity monitor systems found short-term changes in physical activity with self-monitoring, but no demonstration of superiority when the systems were compared with other interventions.[11] Another review of studies on the viability of using mobile technology for measuring and influencing physical activity found that most apps allow users to document their activity, set goals, review real-time feedback, connect to a social support network, and access online expertise.[12] However, less common among these apps were prompts to act and opportunities for problem solving and action planning, which are crucial constructs that translate intention into long-term behavior change.[13]

Sensor technologies
Sensor technologies have begun to enter the telehealth landscape and are primarily focused on continuous monitoring and precise diagnostics to inform management of various health conditions and diseases.[14-17] Sensors can be integrated into a watch or arm band or adhesive bandages and clothing, and then programmed to collect data on cardiac rhythm, heart rate, blood pressure, respiration, oxygen saturation, galvanic skin response, glucose levels, body temperature, body motions, ambient temperature, and global positioning. For health care providers, sensor inputs can permit remote monitoring, real-time teleconferencing, and timely care for patients with chronic diseases. For both patients and clinicians, telehealth supported by sensors can have profound implications. Clinicians can provide timely and patient-centred care to those living at a distance with chronic disease and can coordinate care when multiple providers are involved, reducing costs to the health care system.

A current clinical example is the management of paroxysmal atrial fibrillation with a mobile ECG and app that monitors the patient’s electrical rhythm to detect frequency and patterns of arrhythmias, and may even allow patients to share ultrasound and electrocardiogram data with their health care provider.[18-20] Telemonitoring with sensors can also support self-management of chronic diseases and detect early signs of deterioration in health requiring immediate treatment and advice.[21] Studies to date have demonstrated some clinical promise for the use of home telemonitoring in the context of heart failure and diabetes. A recent Cochrane review found that telemonitoring was an effective way to lower levels of glycated hemoglobin and low-density lipoprotein.[22] Although several studies on heart failure have produced conflicting results regarding the overall benefits of home monitoring,[23-26] systematic reviews have suggested that home telemonitoring reduces all-cause mortality and hospitalizations, and improves quality of life compared with usual care.[22,27] In addition, features such as automated and mobile telemonitoring appear to be more effective compared with other forms of home telemonitoring.[27]

Further studies are needed to determine how home health monitoring can improve patient safety during the transition from acute care to community care, and to examine the impact of home monitoring on health care costs. TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), an initiative of the University of British Columbia and Vancouver Coastal Health, is seeking to do this with prospective trials designed to uncover how telemonitoring can support the safety of heart failure patients discharged from hospital to home.[28]

Mobile apps, wearables, and sensors in the clinical setting
Even though mobile apps, wearables, and sensor technologies are promising, further research is needed to validate their use and long-term impact.[29] This research will require the collaboration of clinicians, health researchers, engineers, and computer scientists.[30] Understanding the possible risks of using these technologies, from physiological harm to breaching of privacy and confidentiality with insecure devices, and how to mitigate any risks is also important. Other important issues to consider include patient anxiety with overuse of technologies, health data piracy, self-diagnosis resulting from overreliance on self-monitoring, and patients not seeking help appropriately. These technologies should be used only as complementary tools in the treatment and prevention of health conditions and disease and should not be used in isolation by patients who self-diagnose and self-manage without consulting a health professional. 

各大资产管理公司的专家们表示,评估亚洲ETF潜力的难题在于日本市场在地区所占比重过大,以及日本央行(Bank of Japan)扮演的角色过大。日本央行每年购买6万亿日元(合540亿美元)的ETF,这扭曲了市场。

Instant Heart Rate by Azumio.[31] A free app downloadable to both Apple and Android operating systems that measures heart rate and displays a monitoring strip. As well as helping users accurately track their heart rates, the app is capable of detecting irregular rhythms when palpitations occur. 

Sleep Time by Azumio.[32] A free app that monitors sleep patterns, sleep efficiency, and also acts as an alarm clock. Users can know how often they go into light and deep sleep, and recognize how much of these types of sleep will be necessary for them to feel rested, thereby quantifying the amount of true sleep they need and not just how long they should stay in bed. 

Bellybio Interactive Breating by RelaxLine.[33] A free app that helps users pace their breathing to achieve calmness. Placing the mobile phone against the abdomen, users can follow the sounds emitted to practise deep, abdominal breathing using this simple yet surprisingly effective tool. 

But, when the skeletal remains were analyzed, the researchers found that the tombs had been reused multiple times. Some of the tombs contain more than 10 occupants, and the"repeated multiple burials warrant further study," the researcherswrote.
如果你是一名创业家,那么未来永远是光明的,基于传统服务的数字化来创立新企业的机会简直取之不尽。

清华大学(Tsinghua)与欧洲工商管理学院(Insead University)合办的Tiemba项目排名上升两位,在2015年全球EMBA排行榜中摘得桂冠,而Trium项目的排名回落至第三,仅在头名位置维持一年时间。
Please accept our wishes for you and yours for a happy New Year.
Yet for all Russia's pretence about a rebalancing of priorities towards Asia, since the fallout over Ukraine, it still measures itself against the West, and America in particular.
《南华早报》援引当地公安局李剑敏告诉新华社记者的消息:“整个加工车间里又腥又臭,人进去待一两分钟就受不了。”
Stand: Whole Foods CEO John Mackey called for 'Conscious Capitalism'
“在古代,库车的名字在中国文学中叫做龟兹,是建立在西域绿洲上的一个非常强大的城邦,研究人员写到。

Discernment to determine whether a particular app, wearable, or sensor can be effective.
Expertise and experience to guide patients on the use of technology.
Partnership with patients in pursuit of optimal health through technology use.
Trials to closely monitor benefits and drawbacks.
Humility to recognize that patients may know and invest much more time than physicians in looking for these tools.34

Conclusions
Based on today’s rapid pace of development and public enthusiasm for the technology marketplace, health apps, wearables, and sensors will soon become integral to our patients’ pursuits of good health and will need to be integrated in clinical practice. Physicians must be active agents in these evolutionary times, guiding patients, advocating for evidence to support the use of technologies, and participating in the development and incorporation of technology in patient wellness journeys. Through clinical stewardship and partnership with patients, physicians can use their expertise and experience to guide the growth of innovations into mainstream health care.

Competing interests
Dr Ho receives no personal financial compensation as the principal investigator of TEC4Home (Telehealth for Emergency-Community Continuity of Care Connectivity via Home Tele-monitoring), a project funded by a Canadian Institutes of Health Research grant. This grant is matched by the Michael Smith Foundation for Health Research and the BC Ministry of Health, with additional support provided by TELUS Health and Sentrian. TELUS Health, Cisco, and Avizia have also provided equipment for display in Dr Ho’s Demonstration and Simulation Studio for Health (DaSSH) at UBC. Mr Yao and Dr Lauscher have no competing interests to declare.


住建部《建筑木结构阻燃涂料》正式获批


References

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2. Swan M. Emerging patient-driven health care models: An examination of health social networks, consumer personalized medicine and quantified self-tracking. Int J Environ Res Public Health 2009;6:492-525.

3. Gao Y, Li H, Luo Y. An empirical study of wearable technology acceptance in healthcare. Ind Manag Data Syst 2010;115:1704-1723.

4. Kim KJ, Shin DH. An acceptance model for smart watches: Implications for the adoption of future wearable technology. Internet Res 2015;25:527-541.

5. West JH, Hall PC, Hanson CL, et al. There’s an app for that: Content analysis of paid health and fitness apps. J Med Internet Res 2012;14:e72.

6. Abroms LC, Padmanabhan N, Thaweethai L, Phillips T. iPhone apps for smoking cessation: A content analysis. Am J Prev Med 2011;40:279-285.

7. Cowan LT, Van Wagenen SA, Brown BA, et al. Apps of steel: Are exercise apps providing consumers with realistic expectations? A content analysis of exercise apps for presence of behavior change theory. Health Educ Behav 2013;40:133-139.

8. Azar KM, Lesser LI, Laing BY, et al. Mobile applications for weight management. Am J Prev Med 2013;45:583-589.

9. Breland JY, Yeh VM, Yu J. Adherence to evidence-based guidelines among diabetes self-management apps. Transl Behav Med 2013;3:277-286.

10. Lyons EJ, Lewis ZH, Mayrsohn BG, Rowland JL. Behavior change techniques implemented in electronic lifestyle activity monitors: A systematic content analysis. J Med Internet Res 2014;16:e192.

11. Lewis ZH, Lyons EJ, Jarvis JM, Baillargeon J. Using an electronic activity monitor system as an intervention modality: A systematic review. BMC Public Health 2015;15:585.

12. Bort-Roig J, Gilson ND, Puig-Ribera A, et al. Measuring and influencing physical activity with smartphone technology: A systematic review. Sports Med 2014;44:671-686.

13. Rhodes RE, Yao CA. Models accounting for intention-behavior discordance in the physical activity domain: A user’s guide, content overview, and review of current evidence. Int J Behav Nutr Phys Act 2015;12:1-14.

14. Chen M, Gonzalez S, Vasilakos A, et al. Body area networks: A survey. Mob Networks Appl 2011;16:171-193.

15. Appelboom G, Camacho E, Abraham ME, et al. Smart wearable body sensors for patient self-assessment and monitoring. Arch Public Health 2014;72:28.

16. Chan M, Estève D, Fourniols JY, et al. Smart wearable systems: Current status and future challenges. Artif Intell Med 2012;56:137-156.

17. Alemdar H, Ersoy C. Wireless sensor networks for healthcare: A survey. Comput Networks 2010;54:2688-2710.

18. Haberman ZC, Jahn RT, Bose R, et al. Wireless smartphone ECG enables large-scale screening in diverse populations. J Cardiovasc Electrophysiol 2015;26:520-526.

19. Ferdman DJ, Liberman L, Silver ES. A smartphone application to diagnose the mechanism of pediatric supraventricular tachycardia. Pediatr Cardiol 2015;36:1452-1457.

20. Baquero GA, Banchs JE, Ahmed S, et al. Surface 12 lead electrocardiogram recordings using smart phone technology. J Electrocardiol 2015;48:1-7.

21. Wootton R. Twenty years of telemedicine in chronic disease management—An evidence synthesis. J Telemed Telecare 2012;18:211-220.

22. Flodgren G, Rachas A, Farmer A, et al. Interactive telemedicine: Effects on professional practice and health care outcomes. Cochrane Database System Rev 2015;(9):CD002098.

23. Mortara A, Pinna GD, Johnson P, et al. Home telemonitoring in heart failure patients: The HHH study (Home or Hospital in Heart Failure). Eur J Heart Fail 2009;11:312-318.

24. Dar O, Riley J, Chapman C, et al. A randomized trial of home telemonitoring in a typical elderly heart failure population in North West London: Results of the Home-HF study. Eur J Heart Fail 2009;11:319-325.

25. Chaudhry SI, Mattera JA, Curtis JP, et al. Telemonitoring in patients with heart failure. N Engl J Med 2010;363:2301-2309.

26. Koehler F, Winkler S, Schieber M, et al. Impact of remote telemedical management on mortality and hospitalizations in ambulatory patients with chronic heart failure: The Telemedical Interventional Monitoring in Heart Failure study. Circulation 2011;123:1873-1880.

27. Kitsiou S, Pare G, Jaana M. Effects of home telemonitoring interventions on patients with chronic heart failure: An overview of systematic reviews. J Med Internet Res 2015;17:e63.

28. TEC4Home Healthcare Innovation Community. Supporting heart failure patient transitions from acute to community care with home telemonitoring technology: A protocol for a provincial randomized controlled trial (TEC4Home). JMIR Res Protoc 2016;5:e198. 

29. Yao C, Ho K. Mobile sensors and wearable technologies. In: Amelung VE, Stein V, Goodwin N, et al., editors. Handbook integrated care. Cham, Switzerland: Springer; 2017.

30. Ho K, Borycki E, Kushniruk A, et al. The health perspective in using digital media for health and wellness. Presented at the IEEE International Digital Media Industry Forum, Boston, MA, 4-6 July 2016.

31. Azumio Inc. Instant heart rate. Accessed 28 August 2017. www.azumio.com/s/instantheartrate/index.html. 

32. Azumio Inc. Sleep time. Accessed 28 August 2017. www.azumio.com/s/sleeptime/index.html. 

33. RelaxLine. BellyBio. Accessed 28 August 2017. https://itunes.apple.com/ca/app/bellybio-interactive-breathing/id353763955?mt=8.

34. Ho K. How health information technologies are enhancing health of patients and their doctors. Presentation at the Alberta Medical Association 2015 Spring Representatives Forum, Edmonton, AB, 13 March 2015.


目前全国11个省的52所高校配备了自动售货机,出售艾滋病检测试剂以供学生自查。
还是得作秀
公告宣称:"我们已经报警,并且收集了证据来维护公司的声誉。而那些泄露裸照的人将被按照法律惩处。"
Female founders in Silicon Valley will raise more money next year, as sexual harassment scandals have forced investors to rethink their habit of backing ventures founded by mainly young, white men. Some start-ups founded by men pursued by rumours of unsavoury pasts will not get funding, even if they are a good investment proposition.
我们不妨借用一些狄更斯的名句,来回顾下几乎各种战略都失灵的2014年:
11. 《黑豹党:革命先锋》(The Black Panthers: Vanguard of the Revolution),导演:斯坦利?尼尔森(Stanley Nelson)。
I always judge the tank on actions and not by words. So, when teams say they're not in the tank and then run out a bunch of undrafted free agents while injuries to star players linger, that's when you know it's on.
平均工作经验:12年
Only two people know the Oscars winners list and supervise the counting procedures - PwC tax adviser Martha Ruiz and Brian Cullinan an accountant.
A research team at the University of Chicago has solved this problem, producing hands that send electric signals to the brain. They've begun with monkeys as test subjects, studying the animals to see how their brains respond to touch. When outfitted with prosthetic hands that stimulate their brains that way, the monkeys respond just as though they physically touch objects themselves.

Kendall Ho, MD, FRCPC, Christopher Yao, MSc, Helen Novak Lauscher, PhD. Part 2: Health apps, wearables, and sensors: The advancing frontier of digital health. BCMJ, Vol. 59, No. 10, December, 2017, Page(s) 503-506 - Clinical Articles.



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Halpern SD, Ubel PA, Caplan AL, Marion DW, Palmer AM, Schiding JK, et al. Solid-organ transplantation in HIV-infected patients. N Engl J Med. 2002;347:284-7.

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阿里巴巴旗下品牌淘宝位居第二,品牌价值429亿美元,超过了中国移动、百度和中国工商银行。
单词flimsy 联想记忆:
她说:“我们一直在寻找他的遗骨,终于找到了。现在是为他恢复名誉的时候了。”
立场:呼吁进行移民改革

Whenever I talk to people about the future, I'm struck by their belief that it is knowable. The impression I get is that most people imagine the future like a book ending: already written and readable if you can just steal a quick look at the last few pages. What they find difficult is accepting that the pages aren't written yet. The future hasn't happened, hasn't even been planned--and cannot be known because it doesn't exist.

  • Only the first three authors are listed, followed by "et al."
  • 商务部关于美国对中国输美产品加征关税的声明
  • 央行降息开发商瓜分政策红利 分析称房价难再跌


周二,萨尔州成为德国第一个禁止外国政客拉票的地区。德国数个地方议会基于消防安全等技术原因,取消了土耳其部长们原计划的拉票集会。
如果这个目标真的能够实现,届时特斯拉的规模将超过林肯(Lincoln)和保时捷(Porsche)等豪车品牌的美国分支。这两个老字号豪车品牌都有更多样化的产品阵容、长期的经销商网络、成熟的营销和广告策略。特斯拉如果真的能卖出预期的数字,那么其销量的半数将来自现有的Model S轿车,其它一半则来自明年年初才会量产的Model X七座跨界车。

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